Periodic antacid use should not be problematic as long as the antacid and enteric-coated naproxen administration are separated by at least 2 hours. Calcium; Vitamin D: (Moderate) The chronic use of aluminum-containing antacids (e.g., aluminum hydroxide-containing antacids) for hyperphosphatemia in conjunction with vitamin D can lead to aluminum retention and possible toxicity. Although the exact mechanism is not known, theoretically it may be due to alterations in gastric pH. This interaction can be avoided by separating the administration of pseudoephedrine and antacids by 1 to 2 hours. Mefenamic Acid: (Moderate) Ingestion of mefenamic acid with antacids is not recommended. Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine: (Major) The therapeutic action of methenamine requires an acidic urine. Although the magnitude of the interaction is not great, an occasional patient may be affected and the interaction may lead to subtherapeutic phenytoin concentrations. Acetaminophen; Pentazocine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Erlotinib displays pH-dependent solubility with decreased solubility at a higher pH; the increased gastric pH resulting from antacid therapy may reduce the bioavailability of erlotinib. Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide: (Moderate) Separate administration of elvitegravir and antacids by at least 2 hours. DISCOUNT ONLY - NOT INSURANCE. Aluminum/magnesium hydroxide antacids decrease the AUC of mycophenolic acid by about 17% when given as mycophenolate mofetil. Hydrocodone; Potassium Guaiacolsulfonate: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. To minimize drug interactions, administer chenodiol at least 1 hour before or at least 2 hours after the aluminum-based antacid. The simultaneous administration of an antacid with dasatinib decreased the Cmax and AUC of dasatinib by 58% and 55%, respectively.
If hypokalemia occurs or persists, consider reducing the dichlorphenamide dose or discontinuing dichlorphenamide therapy. Antacids may decrease the absorption of digoxin. Rectal administration of sodium polystyrene sulfonate may reduce the severity of these interactions. If you have any of the following health problems, consult your doctor or pharmacist before using this product: frequent alcohol use, dehydration/fluid restriction, kidney problems (including kidney stones). Due to the formation of ionic complexes in the gastrointestinal tract, simultaneous administration results in lower elvitegravir plasma concentrations. Possible adverse metabolic effects associated with aluminum and magnesium ingestion may occur in this age group. The accumulation of aluminum can lead to dialysis encephalopathy, dialysis osteomalacia, or 'dialysis dementia' (impaired cognition). Sarecycline: (Major) Separate administration of sarecycline and antacids by 2 to 3 hours. I understand I can opt out at any time, by clicking the 'unsubscribe' button found in the price drop alert emails I receive. Drugs used to treat constipation, such as laxatives, would counteract the effect of antidiarrheals.
Simethicone helps break up gas bubbles in the gut. Antacids may decrease the absorption of oral iron preparations. Periodic antacid use should not be problematic as long as the antacid and enteric-coated naproxen administration are separated by at least 2 hours. Increased urine alkalinity also can inhibit the conversion of methenamine to formaldehyde, which is the active bacteriostatic form; concurrent use of methenamine and urinary alkalizers is not recommended. (Moderate) Concurrent administration of rilpivirine and antacids may significantly decrease rilpivirine plasma concentrations, potentially resulting in treatment failure. Examples of compounds that may interfere with quinolone bioavailability include antacids that contain aluminum hydroxide. Nevertheless, serum phenytoin levels and clinical response should be closely monitored if these agents are co-administered. It is used to relieve the symptoms of indigestion, heartburn, sour stomach, and the discomfort caused by gas. Administer chloroquine and antacids at least 4 hours apart. Calcium Carbonate; Risedronate: (Moderate) Magnesium hydroxide will interfere with the absorption of risedronate. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Sodium Citrate; Citric Acid: (Contraindicated) Avoid coadministration of antacids with citrate salts since increased absorption of aluminum can occur. If aluminum-based antacids are used on a regular basis, an alternative to pseudoephedrine may be considered. In general, it may be prudent to avoid drugs such as antacids in combination with enteric-coated budesonide. Nilotinib: (Moderate) If concomitant use of these agents is necessary, administer the antacid approximately 2 hours before or approximately 2 hours after the nilotinib dose. Coadministration may impair absorption of tetracycline which may decrease its efficacy. This interaction can be avoided by separating the administration of pseudoephedrine and antacids by 1 to 2 hours. Acetaminophen; Chlorpheniramine; Phenylephrine : (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. The clinical effect of this change is not known, but does not appear to be significant. Examples of compounds that may interfere with quinolone bioavailability include antacids that contain magnesium hydroxide. This interaction can be avoided by separating the administration of pseudoephedrine and antacids by 1 to 2 hours.
Amprenavir: (Moderate) Coadministration with antacids decreases amprenavir plasma concentrations. Propranolol; Hydrochlorothiazide, HCTZ: (Moderate) Antacids may reduce the absorption of propranolol. Thyroid hormones: (Moderate) Oral thyroid hormones should be administered at least 4 hours before or after a dose of simethicone. When used as an antacid, magnesium hydroxide is often combined with aluminum salts because the constipating effects of aluminum salts counteract the laxative effects of magnesium salts (see Adverse Reactions).-Simethicone: As an antiflatulent, simethicone has been shown in vitro to disperse and prevent the formation of mucus-surrounded gas pockets in the GI tract. This product may react with other medications (including digoxin, iron, pazopanib, tetracycline antibiotics, quinolone antibiotics such as ciprofloxacin), preventing them from being fully absorbed by your body. This interaction can be avoided by separating the administration of pseudoephedrine and antacids by 1 to 2 hours. Administer tipranavir and ritonavir 2 hours before or 1 hour after antacids. Antacids containing alkalinizing agents such as sodium bicarbonate can alkalinize the urine, thereby decreasing the effectiveness of methenamine by increasing the amount of non-ionized drug available for renal tubular reabsorption. Norethindrone Acetate; Ethinyl Estradiol; Ferrous fumarate: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. Separating times of administration may help limit any possible interaction. (Moderate) Concurrent administration of rilpivirine and antacids may significantly decrease rilpivirine plasma concentrations, potentially resulting in treatment failure. Didanosine, ddI: (Minor) The side effects associated with aluminum hydroxide may potentially be increased during concurrent use with didanosine, ddI because some ddI products also contain similar antacid ingredients. In the management of esophageal reflux, the increase in gastric pH produced by antacids, including magnesium hydroxide, causes an increase in the lower esophageal sphincter pressure. This interaction results in a 25% reduction in the bradycardic effect of sotalol (measured at rest). Concurrent use may reduce the efficacy of levothyroxine by binding and delaying or preventing oral absorption, potentially resulting in hypothyroidism. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Prescription prices may vary from pharmacy to pharmacy and are subject to change. If aluminum-based antacids are used on a regular basis, an alternative to pseudoephedrine may be considered. Calcium products may form complexes with phenytoin that are nonabsorbable. Monitor serum potassium levels to determine the need for potassium supplementation and/or alteration in drug therapy. The need to stagger doses of propranolol has not been established, but may be prudent. Bismuth Subcitrate Potassium; Metronidazole; Tetracycline: (Moderate) Separate administration of tetracycline and antacids by 2 to 3 hours. Halofantrine: (Major) The oral absorption of halofantrine may be hindered by the concomitant use of antacids, and perhaps other antacids. Ferric Maltol: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. Aluminum hydroxide, often found in antacids, interferes with the intestinal absorption of thyroid hormones. Dasatinib: (Moderate) Separate the administration of dasatinib and antacids by at least 2 hours if these agents are used together. Aluminum hydroxide and magnesium hydroxide are antacids that partially neutralize gastric acid secretions, thereby increasing the pH of the gastric contents. Administer cholic acid at least 1 hour before or 4 to 6 hours (or the maximal interval possible) after an aluminum-based antacids. The dose of digoxin may need to be adjusted. Gefitinib: (Major) Avoid coadministration of antacids with gefitinib if possible due to decreased exposure to gefitinib, which may lead to reduced efficacy. To decrease the risk of virologic failure, avoid use of antacids for at least 2 hours before and at least 4 hours after administering rilpivirine. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist about using this drug safely. If aluminum-based antacids are used on a regular basis, an alternative to pseudoephedrine may be considered.
It is recommended to separate times of administration. Loratadine; Pseudoephedrine: (Minor) It appears that antacids containing aluminum hydroxide may increase pseudoephedrine plasma concentrations. In the small intestine, aluminum chloride is rapidly converted to insoluble, poorly absorbed, basic aluminum salts. The chloride salt of aluminum produced in the stomach reacts with bicarbonate in the small intestine to minimize the risk of systemic alkalosis. Norfloxacin absorption may be reduced as quinolone antibiotics can chelate with divalent or trivalent cations. If you have diabetes, consult your doctor or pharmacist about using this drug safely. If aluminum-based antacids are used on a regular basis, an alternative to pseudoephedrine may be considered. Antacid administration two hours after the sotalol dose does not alter sotalol pharmacokinetics or pharmacodynamics. Talk to your pharmacist for more details. The aluminum in this product can cause constipation. Staggering the times of administration may avoid this pharmacokinetic interaction. Simethicone is not known to interfere with gastric secretion or nutrient absorption.-Special PopulationsRenal Impairment-Magnesium Hydroxide: In patients with significant renal impairment, the amount of magnesium absorbed from aluminum hydroxide; magnesium hydroxide; simethicone products is significant enough to produce hypermagnesemia. This interaction can be avoided by separating the administration of pseudoephedrine and antacids by 1 to 2 hours. Dexbrompheniramine; Pseudoephedrine: (Minor) It appears that antacids containing aluminum hydroxide may increase pseudoephedrine plasma concentrations. Simultaneous administration should be avoided; separate dosing by at least 2 hours to limit an interaction. Demeclocycline: (Moderate) Separate administration of demeclocycline and antacids by 2 to 3 hours. Administer antacids at least 2 hours before or 2 hours after the 100 mg capsule or 200 mg tablet. The chemical structure of these GI drugs that contain polyvalent cations, such as magnesium hydroxide, can bind dolutegravir in the GI tract. In Canada - Call your doctor for medical advice about side effects. The increase in gastric pH inhibits the proteolytic action of pepsin, an effect that is particularly important in patients with peptic ulcer disease. (Major) Avoid coadministration of aluminum hydroxide with citrate salts due to the potential for increased absorption of aluminum. Aluminum hydroxide, often found in antacids, interferes with the intestinal absorption of thyroid hormones. It may be advisable to separate chlorpromazine administration from antacids by 1 to 2 hours. Guaifenesin; Hydrocodone; Pseudoephedrine: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Brompheniramine; Pseudoephedrine: (Minor) It appears that antacids containing aluminum hydroxide may increase pseudoephedrine plasma concentrations. This survey is being conducted by the WebMD marketing sciences department. If aluminum-based antacids are used on a regular basis, an alternative to pseudoephedrine may be considered. At higher pH values, iron is more readily ionized to its ferric state and is more poorly absorbed.
(Moderate) To minimize an interaction, administer thyroid hormones at least 4 hours before or after antacids or other drugs containing aluminum hydroxide. Zalcitabine, ddC: (Moderate) The absorption of zalcitabine is moderately reduced when coadministered with aluminum hydroxide. Gastric acidity is an essential requirement for adequate absorption of levothyroxine. At least 4 hours should elapse between doses of aluminum hydroxide-containing antacids and ethambutol. This program does not make payments directly to pharmacies. Vitamin D: (Moderate) The chronic use of aluminum-containing antacids (e.g., aluminum hydroxide-containing antacids) for hyperphosphatemia in conjunction with vitamin D can lead to aluminum retention and possible toxicity. Acetaminophen; Dextromethorphan; Phenylephrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Chloroquine: (Major) Chloroquine absorption may be reduced by antacids. At higher pH values, iron is more readily ionized to its ferric state and is more poorly absorbed. Sotorasib: (Moderate) Avoid coadministration of sotorasib and gastric-reducing agents, such as antacids. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Methenamine: (Major) The therapeutic action of methenamine requires an acidic urine. This interaction can be avoided by separating the administration of pseudoephedrine and antacids by 1 to 2 hours. Omadacycline: (Moderate) Separate administration of omadacycline and antacids by 4 hours. Separate the administration of bosutinib and antacids by more than 2 hours. Moxifloxacin: (Major) Administer oral moxifloxacin at least 4 hours before or 8 hours after magnesium hydroxide. Coadministration may impair absorption of demeclocycline which may decrease its efficacy. Homatropine; Hydrocodone: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Ask your pharmacist if you have any questions about your product or its use. Simultaneous oral administration should be avoided when feasible; separate dosing by at least 2 hours to limit an interaction. Chelation of divalent cations with levofloxacin is less than with other quinolones. Ethambutol: (Moderate) Aluminum hydroxide can reduce the rate or extent of ethambutol absorption. Budesonide; Formoterol: (Moderate) Enteric-coated budesonide granules dissolve at a pH more than 5.5. One case of grand mal seizure has been reported in a patient with chronic hypocalcemia of renal failure who was given sodium polystyrene with magnesium hydroxide as laxative. Antacids containing alkalinizing agents such as sodium bicarbonate can alkalinize the urine, thereby decreasing the effectiveness of methenamine by increasing the amount of non-ionized drug available for renal tubular reabsorption. Bismuth Subsalicylate; Metronidazole; Tetracycline: (Moderate) Separate administration of tetracycline and antacids by 2 to 3 hours. Vitamin D: (Moderate) Magnesium-containing antacids, such as magnesium hydroxide, should be used cautiously in patients receiving vitamin D (cholecalciferol). Aluminum hydroxide; magnesium hydroxide; simethicone should be used cautiously in geriatric patients and in patients with renal impairment or renal disease because of the increased risk of developing hypermagnesemia and magnesium toxicity and aluminum toxicity, especially dialysis dementia in dialysis patients with long term use of aluminum containing antacids. Antacids may decrease the absorption of oral iron preparations. Consider closely monitoring blood glucose concentrations. Budesonide: (Moderate) Enteric-coated budesonide granules dissolve at a pH more than 5.5. This interaction can be avoided by separating the administration of pseudoephedrine and antacids by 1 to 2 hours. Do not freeze. Using an antacid that contains only aluminum along with this product can help control diarrhea. Ingestion times of phenytoin capsules and calcium antacids should be staggered in patients with low serum phenytoin levels to prevent absorption difficulties. Taking these drugs simultaneously may result in reduced bioavailability of dolutegravir. Increased urine alkalinity also can inhibit the conversion of methenamine to formaldehyde, which is the active bacteriostatic form; concurrent use of methenamine and urinary alkalizers is not recommended. Alendronate; Cholecalciferol: (Moderate) Separate administration of alendronate and aluminum hydroxide by at least 30 minutes. Lifestyle changes such as stress reduction programs, stopping smoking, limiting alcohol, and diet changes (such as avoiding caffeine, fatty foods, certain spices) may increase the effectiveness of this medication. Follow dose with a full glass of water. Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. Acalabrutinib: (Moderate) Separate the administration of acalabrutinib and antacids by at least 2 hours if these agents are used together. Because deferasirox may bind to aluminum instead of iron, aluminum containing antacids should not be administered concurrently in order to avoid a possible decreased efficacy of either therapy. Phosphorus: (Moderate) Phosphate may bind magnesium salts and magnesium-containing antacids (e.g., magnesium carbonate, magnesium hydroxide) may limit phosphorus absorption or phosphorus may limit magnesium absorption. Increased urine alkalinity also can inhibit the conversion of methenamine to formaldehyde, which is the active bacteriostatic form; concurrent use of methenamine and urinary alkalizers is not recommended. Before taking this product, tell your doctor or pharmacist if you are allergic to aluminum hydroxide; or to magnesium; or to simethicone; or if you have any other allergies. Hydroxychloroquine: (Moderate) Hydroxychloroquine absorption may be reduced by antacids as has been observed with the structurally similar chloroquine. Carbinoxamine; Hydrocodone; Pseudoephedrine: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Aluminum hydroxide, often found in antacids, interferes with the intestinal absorption of thyroid hormones. Ciprofloxacin absorption may be reduced as quinolone antibiotics can chelate with divalent or trivalent cations. Carbonic anhydrase inhibitors: (Moderate) Diuretics may interfere with the kidneys ability to regulate magnesium concentrations. More hydrogen ions are lost from the stomach than are lost from the intestine, resulting in metabolic alkalosis. Ticlopidine: (Major) Administration of ticlopidine after antacids resulted in an 18% decrease in plasma levels of ticlopidine. Antacids containing alkalinizing agents such as sodium bicarbonate can alkalinize the urine, thereby decreasing the effectiveness of methenamine by increasing the amount of non-ionized drug available for renal tubular reabsorption. If antacids must be used while a patient is taking glyburide, give the glyburide at least 2 hours prior to the antacid. Nausea, constipation, diarrhea, or headache may occur. Simultaneous administration should be avoided; separate dosing by at least 2 hours to limit an interaction. The gas bubbles coalesce and are more quickly eliminated by flatus, belching, or absorption into the bloodstream.
Ezetimibe; Simvastatin: (Minor) Antacids may decrease the peak plasma concentration (Cmax) of total ezetimibe by 30%. Separate doses of atenolol and aluminum-containing antacids or supplements when possible by at least 2 hours to minimize this potential interaction. Velpatasvir solubility decreases as pH increases; therefore, drugs that increase gastric pH are expected to decrease the concentrations of velpatasvir, potentially resulting in loss of antiviral efficacy. Periodic antacid use should not be problematic as long as the antacid and enteric-coated naproxen administration are separated by at least 2 hours. Separate doses of atenolol and aluminum-containing antacids or supplements when possible by at least 2 hours to minimize this potential interaction. Codeine; Guaifenesin; Pseudoephedrine: (Minor) It appears that antacids containing aluminum hydroxide may increase pseudoephedrine plasma concentrations. The need to stagger doses of propranolol has not been established, but may be prudent. If your acid problems last or get worse after you have used this product for 1 week, or if you think you have a serious medical problem, seek immediate medical attention. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Increased urine alkalinity also can inhibit the conversion of methenamine to formaldehyde, which is the active bacteriostatic form; concurrent use of methenamine and urinary alkalizers is not recommended.
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